My group at UC Riverside has developed a diverse physical chemistry research program unified through applications of nuclear magnetic resonance (NMR). There are now three distinct research directions in my group encompassing the following areas: (1) Structure and Dynamics with Solid-State NMR: emphasizing the development of novel experimental and theoretical methods; (2) Dynamic NMR: a quantum-statistical treatment of chemical exchange and new applications to kinetic and thermodynamic studies of small molecules in solution and gas phases; and (3) New Physics in NMR: quantum computing in the solid state with single crystal NMR.

Selected Publications

C.M. Rienstra, M.E. Hatcher, L.J. Mueller, B. Sun, S.W. Fesik, and R.G. Griffin, “Efficient Multispin Homonuclear Double-Quantum Recoupling Magic-Angle Spinning NMR: 13C-13C Correlation Spectroscopy of U-13C-Erythromycin A,” Journal of the American Chemical Society 120(41), 10602-10612 (1998)

L.J. Mueller and D.P. Weitekamp, “Quantum-Statistical Corrections to Dynamic Nuclear Magnetic Resonance,” Science, 283, 61-65 (1999)

C.A. Reed, K-C Kim, R.D. Bolskar, and L.J. Mueller, “Taming Superacids: Stabilizaiton of Fullerene Cations HC60+ and C60. +,” Science, 289, 101-104 (2000)

W.H. Okamura, G-D Zhu, D.K. Hill, R.J. Thomas, K. Ringe, D.B. Borchardt, A.W. Norman, and L.J. Mueller, “Synthesis and NMR Studies of 13C Labeled Vitamin D Metabolites,” Journal of Organic Chemistry, 67(5), 1637-1650 (2002)

L.J. Mueller, D.W. Elliott, K-C Kim, C.A. Reed, and P.D.W. Boyd, “Establishing Through-Bond Connectivity in Solids with NMR: Structure and Dynamics in HC60+,” Journal of the American Chemical Society, 124(32), 9360-9361 (2002)

K-C Kim, C.A. Reed, D.W. Elliott, L.J. Mueller, F. Tham, L. Lin, J.B. Lambert, “Crystallographic Evidence for a Free Silylium Ion,” Science, 297, 825-827 (2002)

C.M. Rienstra, M. Hohwy, L.J. Mueller, C.P. Jaroneic, B. Reif, and R.G. Griffin, “Determination of Multiple Torsion-Angle Constraints in U-15N-13C-Labeled Peptides: 3D-1H -15N -13C-1H Dipolar Chemical Shift NMR Spectroscopy in Rotating Solids,” Journal of the American Chemical Society, 124(40) 11908-11922 (2002)

Christopher A. Reed, Kee-Chan Kim, Evgenii S. Stoyanov, Daniel Stasko, Fook S. Tham, Leonard J. Mueller, Peter D.W. Boyd, “Isolating Benzenium Ion Salts,” Journal of the American Chemical Society, 125(7), 1796-1804 (2003)

L.J. Mueller and D.W. Elliott, “Correlated Tensor Interactions and Rotational-Echo Double-Resonance of Spin Clusters,” Journal of Chemical Physics, 118(19), 8873-8881 (2003)

G.M. Leskowitz, R.A. Olsen, N. Ghaderi and L.J. Mueller, “Three-Qubit NMR Quantum Information Processing with a Single-Crystal Solid,” Journal of Chemical Physics, 119(3), 1643-1649 (2003)

R.A. Olsen, L. Liu, N. Ghaderi, A. Johns, M.E. Hatcher, and L.J. Mueller, “The Amide Rotational Barriers in Picolinamide and Nicotinamide: NMR and Ab Initio Studies,” Journal of the American Chemical Society, 125(33)10125-10132 (2003)

R.A. Olsen, J. Struppe, D.W. Elliott, R.J. Thomas and L.J. Mueller, “Through-Bond 13C-13C Correlation at the Natural Abundance Level: Refining Dynamic Regions in the Crystal Structure of Vitamin-D3 with Solid-State NMR,” Journal of the American Chemical Society, 125(39), 11784-11785 (2003)

L.J. Mueller, D.W. Elliott, G.M. Leskowitz, J. Struppe, R.A. Olsen, K-C Kim and C.A. Reed, “Uniform-Sign Cross-Peak Double-Quantum-Filtered Correlation Spectroscopy,” Journal of Magnetic Resonance 168(2), 327-335 (2004)

G.M. Leskowitz and L.J. Mueller, “State Interrogation in Nuclear Magnetic Resonance Quantum Information Processing”, Physics Review A 69(5-A), 052302/1-052302/9 (2004)

A. Rodriguez, R.A. Olsen, N. Ghaderi, D. Scheschekewitz, F.S. Tham, L.J. Mueller and G. Bertrand “Evidence for the Co-Existence of Two Bond-Stretch Isomers in Solution,” Angewandte Chemie International Edition 43(37), 4880-4883 (2004)

G.M. Leskowitz, N. Ghaderi, R.A. Olsen, K. Pederson, M.E. Hatcher, and L.J. Mueller, “The Amide Rotational Barrier in Isonicotinamide: Dynamic NMR and Ab Initio Studies,” Journal of Physical Chemistry A, 109(6), 1152-1158 (2005)

L. Chen, R.A. Olsen, D.W. Elliott, J.M. Boettcher, D.H. Zhou, C.M. Rienstra, and L.J Mueller, “Constant-Time Through-Bond 13C Correlation Spectroscopy for Assigning Protein Resonances with Solid-State NMR Spectroscopy,” Journal of the American Chemical Society, 128(31), 9992-9993 (2006)

R.A. Olsen, D. Borchardt, L. Mink, A. Agarwal, L.J. Mueller, and F. Zaera, “Effect of Protonation on the Conformation of Cinchonidine,” Journal of the American Chemical Society, 128(49), 15594-15595 (2006)

X. Wang, D. Lu, R. Austin, A. Agarwal, L.J. Mueller, Z. Liu, J. Wu, and P. Feng, “Protein Refolding Assisted by Periodic Mesoporous Organosilicas,” Langmuir 23(10), 5735-5739 (2007)

L. Chen, J.M. Kaiser, T. Polenova, J. Yang, C.M. Rienstra, and L.J Mueller, “Backbone Assignments in Solid-State Proteins Using J-Based 3D Heteronuclear Correlation Spectroscopy,” Journal of the American Chemical Society 129(35): 10650-10651 (2007)

R.O. Al-Kaysi, R.J. Dillon, J.M. Kaiser, L.J. Mueller, G. Guirado, and C.J. Bardeen, “Photopolymerization of Organic Molecular Crystal Nanorods,” Macromolecules, 40, 9040-9044 (2007)

L. Chen, J.M. Kaiser, J. Lai, T. Polenova, J. Yang, C.M. Rienstra, and L.J Mueller, “J – Based 2D Homonuclear and Heteronuclear Correlation in Solid-State Proteins,” Magnetic Resonance in Chemistry, 45, S84-S92 (2007)

L. Mink, Z. Ma, R.A. Olsen, J.N. James, D.S. Sholl, L.J. Mueller, and F. Zaera, “The Physico-Chemical Properties of Cinchona Alkaloids Responsible for their Unique Performance in Chiral Catalysis,” Topics in Catalysis, 48(1-4), 120-127 (2008)

S. Yaghmaei, S. Khodagholian, J.M. Kaiser, F.S. Tham, L.J. Mueller, and T.H. Morton, “Chelation of a Proton by an Aliphatic Tertiary Diamine,” Journal of the American Chemical Society, 130(25) 7836-7838 (2008)

Y. Tian, M. Kayatta, K. Shultis, A. Gonzalez, L.J. Mueller, and M.E. Hatcher, “31P NMR Investigation of Backbone Dynamics in DNA Binding Sites,” Journal of Physical Chemistry, in press (2008)