University of California, Riverside

Department of Chemistry



Faculty


 

 

Joseph Genereux
Assistant Professor of Chemistry

 

Swarthmore College - B.A. (2001)
University of California, Irvine - B.S. (2002)
California Institute of Technology - PhD (2003-2009)
The Scripps Research Institute - Postdoc. Fellow (2010-2015)

Office: 320 Chemical Sciences
Phone O/L: (951) 827-3759/3761
Email: joseph.genereux@ucr.edu
Research Area: Analytical Chemistry, Chemical Biology


Research

We are developing in situ quantitative techniques that interrogate the folding, assembly, and misfolding of lipoprotein complexes that are the best molecular signatures of atherosclerotic risk. These will then be applied to attain mechanistic understanding that can lead to new therapeutic and diagnostic approaches for cardiovascular diseases. Ongoing projects include

  • Integrating in situ analytical techniques with multiplexed quantitative proteomics to relate molecular proteostasis pathways to the properties of secreted lipoprotein particles.
  • Molecular characterization of how physiologically relevant oxidation products induce aggregation and enhance atherogenicity of LDL
  • Development of quantitative unbiased proteomic assays to both measure and characterize protein homeostasis in living cells. These will be applied to establish molecular etiologies and identify therapeutic targets for cardiovascular, neurodegenerative, and cancer diseases.

Open Positions

Selected Publications

 

More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Chemistry
Chemical Sciences
501 Big Springs Road

Tel: (951) 827-3789 (Chair's Assistant)
Fax: (951) 827-2435 (confidential)
E-mail: jingsong.zhang@ucr.edu

Footer