Awards
- Chemical Research in Toxicology Young Investigator Award, 2012
- AAAS Fellow, 2011
- ASMS Research Award, 2005
Selected Publications
- Mitra, D.; Luo, X.; Morgan, A.; Wang, J.; Hoang, M.P.; Lo, J.; Guerrero, C. R.; Lennerz, J. K.; Mihm, M. C.; Wargo, J. A.; Robinson, K. C.; Devi, S. P.; Vanover, J. C.; D’Orazio, J. A.; McMahon, M.; Bosenberg, M. W.; Haigis, K. M.; Haber, D.A.; Wang, Y.; Fisher, D. E. Redheads and melanoma risk: pheomelanin synthesis is carcinogenic by a UV-independent mechanism. Nature, 2012, DOI:10.1038/nature11624.
- You, C.; Dai, X.; Yuan, B.; Wang, Y. Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells. J. Biol. Chem., 2012, 287, 40915-40923.
- You, C.; Dai, X.; Yuan, B.; Wang, J.; Wang, J.S.; Brooks, P. J.; Niedernhofer, L. J.; Wang, Y.* A quantitative assay for assessing the effects of DNA lesions on transcription. Nat. Chem. Biol., 2012, 8, 817-822.
- Wang, J.; Clauson, C. L.; Robbins, P. D.; Niedernhofer, L. J. and Wang, Y.* Accumulation of DNA damage with aging is tissue-specific. Aging Cell, 2012, 11, 714-716.
- Zhang, F.; Dai, X. and Wang, Y.* 5-Aza-2’-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis. Mol. Cell. Proteomics 2012, 11, M111.016915.
- Prins, J.; Wang, Y.* Quantitative proteomic analysis revealed 4-(methylnitrosamino)-1-(3-pyridinyl)-1-butanone-induced up-regulation of 20S proteasome in cultured human fibroblast cells. J. Proteome Res. 2012, 11, 2347-2354.
- Tilstra, J. S.; Robinson, A. R.; Wang, J.; Gregg, S. Q.; Clauson, C. L.; Reay, D. P.; Nasto, L. A.; St Croix, C. M.; Usas, A.; Vo, N.; Huard, J.; Clemens, P. R.; Stolz, D. B.; Guttridge, D. C.; Watkins, S. C.; Garinis, G. A.; Wang, Y.; Niedernhofer, L. J.*; Robbins, P. D.* Inhibition of IKK/NF-κB delays the onset of senescence and aging-related degenerative diseases caused by DNA damage. J. Clin. Invest., 2012, 122, 2601-2612.
- Yuan, B.; Zhang, J.; Wang, H.; Xiong, L.; Cai, Q.; Wang, T.; Jacobsen, S.; Pradhane, S. and Wang, Y.* 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1, Cancer Res., 2011, 71, 1904-1911.
- Wang, J.; Yuan, B.; Guerrero, C.; Bahde, R.; Gupta, S.; Wang, Y.* Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method. Anal. Chem., 2011, 83, 2201-2209.
- Xiong, L. and Wang, Y.* Mapping Post-translational Modifications of Histones H2A, H2B and H4 in Schizosaccharomyces pombe. Int. J. Mass Spectrom., 2011, 301, 159-165.
- Xiong, L.; Darwanto, A.; Sharma, S.; Herring, J.; Hu, S.; Filippova, M.; Filippov, V.; Wang, Y.; Chen, C.; Duerksen-Hughes, P.; Sowers, L.C. and Zhang, K.* Mass spectrometric studies on epigenetic interaction networks in cell differentiation. J. Biol. Chem. 2011, 286, 13657-13668.
- Yuan, B.; Wang, J.; Cao, H.; Sun, R. and Wang, Y.* High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing, Nucleic Acids Res., 2011, 39, 5945-5954.
- Yuan, B.; You, C.; Andersen, N.; Jiang, Y.; Moriya, M.; O’Connor, T. R. and Wang, Y.* The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-dG lesions in mammalian cells. J. Biol. Chem., 2011, 286, 17503-17511.
- Wang, J. and Wang, Y.* Synthesis and characterization of oligodeoxyribonucleotides containing a site-specifically incorporated N6-carboxymethyl-2’-deoxyadenosine or N4-carboxymethyl-2’-deoxycytidine. Nucleic Acids Res., 2010, 38, 6774-6784.
- Dong, X.; Cheng, J.; Li, J.* and Wang, Y.* Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS. Anal. Chem., 2010, 82, 6208-6214.
- Weng, M.; Zheng, Y.; Jasti, V.; Champeil, E.; Tomasz, M.; Wang, Y.; Basu, A. and Tang, M. Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acids Res., 2010, 38, 6976-84.
- Yuan, B.; O’Connor, T. R. and Wang, Y.* 6-Thioguanine and S6-methylthioguanine are mutagenic in human cells. ACS Chem. Biol., 2010, 5, 1021-1027.
- Xiong, L.; Zhang, J.; Yuan, B.; Dong, X.; Jiang, X. and Wang, Y.* Global proteome quantification for discovering imatinib-induced perturbation of multiple biological pathways in K562 human chronic myeloid leukemia cells. J. Proteome Res., 2010, 9, 6007-6015.
- Wang, J. and Wang, Y.* Chemical synthesis of oligodeoxynucleotides containing N3- and O4-carboxymethylthymidine and their formation in DNA. Nucleic Acids Res., 2009, 37, 336-345.
- Qiu, H. and Wang, Y.* Exploring DNA-binding proteins with in vivo chemical cross-linking and mass spectrometry. J. Proteome Res., 2009, 8, 1983-1991.
- Cao, H., Jiang, Y. and Wang, Y.* Kinetics of deamination and Cu(II)/H2O2/ascorbate-induced formation of 5-methylcytosine glycol at CpG sites in duplex DNA. Nucleic Acids Res., 2009, 37, 6635-6643.
- Yuan, B. and Wang, Y.* Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine and guanine-S6-sulfonic acid. J. Biol. Chem., 2008, 283, 23665-23670.
- Lai, C.; Cao, H.; Hearst, J.; Corash, L.; Luo, H. and Wang, Y.* Quantitative analysis of DNA interstrand cross-links and monoadducts formed in human cells induced by psoralens and UVA irradiation. Anal. Chem., 2008, 80, 8790-8798.
- Yuan, B.; Cao, H.; Jiang, Y.; Hong, H. and Wang, Y.* Efficient and accurate bypass of N2-(1-carboxyethyl)-2’-deoxyguanosine by DinB DNA polymerase in vitro and in vivo. Proc. Natl. Acad. Sci. USA, 2008, 105, 8679-8684.
- Qiu, H. and Wang, Y.* Quantitative analysis of surface plasma membrane proteins of primary and metastatic melanoma cells. J. Proteome Res., 2008, 7, 1904-1915.
- Hong, H.; Cao, H. and Wang, Y.* Formation and genotoxicity of a guanine-cytosine intrastrand cross-link lesion in vivo. Nucleic Acids Res., 2007, 35, 7118-7127.
- Cao, H.; Jiang, Y. and Wang, Y.* Stereospecific synthesis and characterizations of oligodeoxyribonucleotides containing N2-(1-carboxyethyl)-2’-deoxyguanosine. J. Am. Chem. Soc, 2007, 129, 12123-12130.
- Cao, H. and Wang, Y.* Quantification of oxidative single-base and intrastrand cross-link lesions in unmethylated and CpG-methylated DNA induced by Fenton-type reagents. Nucleic Acids Res., 2007, 35,4833-4844.
- Men, L. and Wang, Y.* The oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro. J. Proteome Res., 2007, 6, 216-225.
- Hong, H. and Wang, Y.* Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2’-deoxyuridine in cellular DNA. Anal. Chem., 2007, 79, 322-326.
- Zou, Y.; Wang, Y.* Mass spectrometric analysis of high-mobility group proteins and their post-translational modifications in normal and cancerous human breast tissues. J. Proteome Res. 2007, 6, 2304-2314.
- Zeng, Y. and Wang, Y.* Sequence-dependent formation of intrastrand crosslink products from the UVB irradiation of duplex DNA containing a 5-bromo-2’-deoxyuridine or 5-bromo-2’-deoxycytidine. Nucleic Acids Res., 2006, 34, 6521-6529.
- Zhang, Q. and Wang, Y.* Generation of 5-(2’-deoxycytidinyl)methyl radical and the formation of intrastrand cross-link lesions in oligodeoxyribonucleotides. Nucleic Acids Res., 2005, 33, 1593-1603.
- Hong, H. and Wang, Y.* Formation of intrastrand crosslink products between cytosine and adenine from UV irradiation of d(BrCA) and duplex DNA containing a 5-bromocytosine. J. Am. Chem. Soc., 2005, 127, 13969-13977.
- Zeng, Y. and Wang, Y.* Facile formation of an intrastrand crosslink lesion between cytosine and guanine upon Pyrex-filtered UV light irradiation of d(BrCG) and duplex DNA containing 5-bromocytosine. J. Am. Chem. Soc. 2004, 126, 6552-3.
- Zhang, Q. and Wang, Y.* Independent generation of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical and its reactivity in dinucleoside monophosphates. J. Am. Chem. Soc. 2004, 126, 13287-97.
- Zhang, Q. and Wang, Y.* Independent generation of 5-(2’-deoxycytidinyl)methyl radical and the formation of a novel crosslink lesion between 5-methylcytosine and guanine. J. Am. Chem. Soc. 2003, 125, 12795-802.
|