University of California, Riverside

Department of Chemistry



Faculty


 

 

Joseph Genereux
Assistant Professor of Chemistry

 

Swarthmore College - B.A. (2001)
University of California, Irvine - B.S. (2002)
California Institute of Technology - PhD (2003-2009)
The Scripps Research Institute - Postdoc. Fellow (2010-2015)

Office: 320 Chemical Sciences
Phone O/L: (951) 827-3759/3761
Email: joseph.genereux@ucr.edu
Research Area: Analytical Chemistry, Chemical Biology


Research

To function properly inside the cell, proteins must achieve their native three-dimensional conformation, and be trafficked to the appropriate subcellular location. Failure at either of these steps deprives the cell of that protein's function, and is the basis of a variety of human diseases. Furthermore, misfolded and mislocalized proteins present a further threat, due to their potential to form toxic conformations. The cell maintains the integrity of the proteome through an extensive and integrated protein homeostasis network of chaperones, degradation factors, and trafficking machineries. Stresses, such as mutations, metabolic disregulation, or exposure to environmental toxins, can overwhelm these machineries. In this case, protein homeostasis is restored by physiological mechanisms that remodel the chaperone environment to prevent misfolded protein accumulation. Although the relevance of these pathways to both fundamental biology and to human health are well established, we still lack the techniques to answer molecular questions of proteostasis across the proteome and in living cells. These questions include: What proteins misfold in response to specific stresses? and how does stress affect protein partitioning within the cell? Our laboratory applies quantitative proteomics approaches to characterize protein conformation and trafficking and help answer these vital questions. We are particularly interested in how stress and stress-responsive signaling affect molecular properties of the proteome. 

Open Positions

Selected Publications

 

More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Chemistry
Chemical Sciences
501 Big Springs Road

Tel: (951) 827-3789 (Chair's Assistant)
Fax: (951) 827-2435 (confidential)
E-mail: leonard.mueller@ucr.edu

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