Research in Chemical Biology at UC Riverside spans a broad area at the Chemistry-Biology interface. The central focus is to develop and apply chemical techniques and tools to study and manipulate biological systems. Research directions include combinatorial chemistry, laboratory engineering of proteins and nucleic acids, DNA damage and mutagenesis, optical and electrochemical biosensors, theoretical and experimental studies on biological dynamics and interactions, spectroscopic characterization of biosystems, and structural biology of biomolecules. Active collaborations exist within the Chemistry Department, as well as with research groups in other departments such as Biochemistry, Cell Biology and Neuroscience, Botany and Plant Science, Entomology, and Institute for Integrative Genome Biology. Please follow the links below to learn more about the individual Chemical Biology research groups at UCR.
Graduate students with a focus in Chemical Biology are expected to receive broad and highly interdisciplinary trainings in bioanalytical, bioorganic and biophysical chemistry.
Faculty Research Description:
Molecular dynamics in chemical and biological systems: The Chang group primarily uses computational methods to investigate the chemistry of biological systems. The goal is to understand how molecules can bind and how molecular flexibility influences ligand binding, and use the knowledge to design drugs and interpret experiments. We have developed new methods to understand ligand binding kinetics.
Research in the Cheng lab focuses on bio- and chemical sensors, functional biomaterials, and label-free surface plasmon resonance (SPR) techniques. We are particularly interested in measurement techniques involving supported lipid membranes, protein microarrays, surface-assisted MS methods, and novel platforms allowing orthogonal detection.
Cellular stresses can interfere with protein folding and trafficking, threatening cellular health. However, we have limited technology to characterize which proteins are impacted by threats to protein homeostasis. Our laboratory develops quantitative proteomics approaches to identify proteome-wide misfolding and mistrafficking in response to stress.
Synthetic Organic, Inorganic and Supramolecular chemistry. Our projects include: the synthesis of biomimetic supramolecular constructs capable of selective molecular recognition; synthesis of new water-soluble catalysts and host molecules; dynamic NMR studies of host:guest interactions; biosensors based on synthetic receptor molecules.
Protein homoeostasis is vital for proper cellular function and involves the turnover, or recycling of proteins. Although many proteins exist briefly, with half-lives of less than 48 hours, other proteins persist for years or longer. In some systems, such as the lens of the eye, proteins never turnover and must remain viable for the entire lifetime of an organism. Degradation of these long-lived proteins occurs in various ways including truncation, misfolding, and post-translational modification. Furthermore, degradation can be spontaneous or enzymatically driven. Many of these processes interact and influence each other, and, in the end, misbehavior of long-lived proteins eventually leads to malfunction and even cell death. We are interested in characterizing the relationships between the properties, structures, and functions of long-lived proteins utilizing mass spectrometry and other related techniques.
Solid-state and solution-state NMR as a probe of structure and dynamics.
Chemical biology, synthetic organic chemistry, nucleic acids, combinatorial chemistry; photochemistry.
The Su Lab operates at the interface of organic synthesis, chemical biology, and polymer science to develop new chemical tools for imaging biomolecules with spatial resolutions exceeding the diffraction limit of conventional fluorescence microscopes. In particular, the Su lab is synthesizing small molecule optical sensors and polymers for visualizing the activity of endogenous biomolecules in fundamental processes and aberrant disease states. Given the interdisciplinary nature of our work, researchers in the Su Lab receive broad-based training that starts from molecular synthesis and extends to chemical biology, biochemistry, or cell & animal work depending on the project.
Design, synthesis and characterization of nucleic acid variants with new properties for molecular recognition, catalysis and replication.
Chemistry and biology of DNA damage, quantitative proteomics. A multi-pronged approach, encompassing synthetic chemistry, mass spectrometry-based bioanalytical chemistry, biochemistry and molecular biology, is employed to understand at the molecular level how structurely defined DNA lesions are repaired and how they compromise the flow of genetic information during DNA replication and transcription. Quantitative proteomics method is used for understanding the molecular mechanisms of action of anticancer drugs and environmental toxicants.
The Xue group develops peptide-based probes for chemical biology applications. Current interest includes 1) structurally rigid peptides that modulate protein-protein interactions, 2) hydrophilic peptides that penetrate the cell membrane, and 3) cyclic peptides that report intracellular protein signaling activities.
Advancement and applications of separation technologies in study of ligand-receptor interaction and protein complex formation; Signal amplification and on-chip sample processing for detection of disease markers; Preparation of bionanomaterials for sensing and biomolecule preconcentration.