University of California, Riverside

Department of Chemistry




Wenwan Zhong
Professor of Chemistry


University of Science and Technology of China - B.S. (1998)
Iowa State University - Ph.D. (2003)
Los Alamos National Laboratory - Postdoc. (2003-2006)

Office: 334 Chemical Sciences
Phone O/L: (951) 827-4925/3532
Research Area: Analytical Chemistry, Chemical Biology
Group Site


The research work in Zhong's group has two main focuses. One is the development of novel bio-analytical techniques for high-throughput detection of biomolecules; the other is to investigate molecular interactions and their functions in biological systems.  For those purposes, we employ various technologies like chromatography, open-channel separation, mass spectrometry, microscopy imaging, microfabrication, etc.

Successful disease diagnosis and cure often rely on specific recognition of disease biomarkers in patient samples, which could be present at very low levels.  Our research efforts have been devoted to development of signal amplification strategies, integration of detection with automatic sample processing, and application of separation technologies in sensing.  Isothermal enzyme reactions and signal enhancement based on nanomaterials are the two main approaches we take to amplify signals from low abundant biomarkers.  Development of the Sample-in-Answer-out devices is undergoing, targeting protein markers and small RNAs in human sera.  Capability of capillary electrophoresis (CE) and flow field flow fractionation (F4) as the detection platform for bioassays have been explored, which permit assays to occur in homogeneous solutions but still need no purification prior to detection.

Molecular interaction, such as protein-protein interaction, is the key event in many cellular processes.  Our group devotes our effort to development of new methods for quick isolation of protein complexes by separation technology and for analysis of the thermodynamics and kinetics of interaction.  CE has been proved to be a highly useful tool for quick measurement of binding affinity.  We have also proved that F4 is more ideal to assess interaction under physiological conditions and accommodate larger complexes, i.e. useful in complex isolation.  In addition, we have been studying how interaction with proteins in biological matrices would impact the behaviors of nanomaterials in cells, which could be related to nanotoxicity.


Selected Publications


More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Department of Chemistry
Chemical Sciences
501 Big Springs Road

Tel: (951) 827-3789 (Chair's Assistant)
Fax: (951) 827-2435 (confidential)